吕剑，博士，讲师，硕士生导师
地址： 湖北省武汉市东湖新技术开发区光谷一路206号
邮编：430205
E-mail: 1020224140@qq.com
教育背景
2015/09–2021/06，华中科技大学，有机化学，博士 （导师：董海 教授）
2011/09–2015/06，安阳工学院，化学工程与工艺，学士
工作履历
2023/01–至今，yl34511线路中心，yl34511线路中心，讲师
2021/06–2022/12，南洋理工大学，博士后（合作导师：刘学伟 教授）
研究领域
糖羟基的选择性功能化；糖苷键的高效构建
糖药物分子的设计与合成
科研项目
1. yl34511线路中心科研启动基金，糖羟基磷酸化的位点/区域选择性研究(23QD37)，10万元，主持；
2. 生物无机化学与药物湖北省重点实验室开放基金，基于选择性磷酰化策略的空肠弯曲杆菌81-176夹膜寡糖片段合成研究(BCMM202405)，2万元，主持。
学术成果
代表性论文：
[1] Jie Zhao, Xiaorui Zhang, Qichang Yang, Haifeng Wang, Shuang-Xi Gu, Qiongjiao Yan, Jian Lv*, Fen-Er Chen*. Synthesis of Deoxy Pyranosides Via Fe(III) Catalyzed Regioselective Thiocarbonylation of Partially Protected Carbohydrates. Eur. J. Org. Chem., 2024, e202400512.
[2] Han Ding, Jian Lv (co-first author), Xiao-Lin Zhang, Yuan Xu, Yu-Han Zhang, Xue-Wei Liu*. Efficient O- and S-glycosylation with ortho-2,2- dimethoxycarbonylcyclopropylbenzyl thioglycoside donors by catalytic strain-release. Chem. Sci., 2024, 15, 3711−3720.
[3] Han Ding, Jian Lyu, Xiao-Lin Zhang, Xiong Xiao, Xue-Wei Liu*. Efficient and versatile formation of glycosidic bonds via catalytic strain-release glycosylation with glycosyl ortho−2,2- dimethoxycarbonylcyclopropylbenzoate donors. Nat. Commun., 2023, 14, 4010−4021.
[4] Jian Lv, Chun-Yang Liu, Yang-Fan Guo, Guang-Jing Feng, Hai Dong*. SnCl2-Catalyzed Acetalation/Selective Benzoylation Sequence for the Synthesis of Orthogonally Protected Glycosyl Acceptors. Eur. J. Org. Chem., 2022, e202101565.
[5] Jian Lv, Jian-Cheng Yu, Guang-Jing Feng, Tao Luo, Hai Dong*. Stannous chloride as a low toxicity and extremely cheap catalyst for regio-/site-selective acylation with unusually broad substrate scope. Green Chem., 2020, 22, 6936−6942.
[6] Jian Lv, Yu Liu, Jia-Jia Zhu, Dapeng Zou, Hai Dong*. Regio/Site-Selective Alkylation of Substrates Containing the Cis-, 1,2- or 1,3-Diol with Ferric Chloride and Dipivaloylmethane as the Catalytic System. Green Chem., 2020, 22, 1139−1144.
[7] Jian Lv, Jia-Jia Zhu, Yu Liu, Hai Dong*. Regioselective Sulfonylation/Acylation of Carbohydrates Catalyzed by FeCl3 Combined with Benzoyltrifluoroacetone and Its Mechanism Study. J. Org. Chem., 2020, 85, 3307−3319.
[8] Jian Lv, Tao Luo, Dapeng Zou, Hai Dong*. Using DMF as Both a Catalyst and Cosolvent for the Regioselective Silylation of Polyols and Diols. Eur. J. Org. Chem., 2019, 2019, 6383–6395.
[9] Jian Lv, Jian-Tao Ge, Tao Luo, Hai Dong*. An inexpensive catalyst, Fe(acac)3, for regio/site-selective acylation of diols and carbohydrates containing a 1,2-cis-diol, Green Chem., 2018, 20, 1987−1991.
[10] Jian Lv, Tao Luo, Ying Zhang, Zhichao Pei*, Hai Dong*. Regio/Site-Selective Benzoylation of Carbohydrates by Catalytic Amounts of FeCl3. ACS Omega, 2018, 3, 17717−17723.
